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#5: Denver, Colorado -- Get major-city sophistication in a location that is one of the world’s natural wonders. While the ski slopes are the big draw in winter, outdoor enthusiasts flock to Denver in warmer weather for challenging mountain hikes and fantastic biking—the city has over 850 miles of bike trails. And thanks to several innovative young chefs, Denver has a lively dining scene. Foodies will have trouble deciding which James Beard-award nominee's restaurant to visit.

Credit: TripAdvisor.com