A UPS cargo plane crashed shortly after takeoff from Louisville Muhammad Ali International Airport on Tuesday evening, killing at least seven people and injuring several more, Kentucky Gov. Andy Beshear said.
According to the Federal Aviation Administration, UPS Flight 2976 went down around 5:15 p.m. local time after departing the airport. Beshear said two businesses were hit when the plane crashed, and two employees are missing.
"First responders are onsite and working hard to extinguish the fire and continue the investigation," Beshear said. "Air monitoring assets have been deployed, and we are working to keep the public informed and keep folks in the area safe."
The McDonnell Douglas MD-11 was headed to Daniel K. Inouye International Airport in Honolulu when it crashed. The cause remains under investigation.
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"This is an incredible tragedy that our community will never forget," said Louisville Mayor Craig Greenberg. "We are so thankful for our brave first responders who have flooded the scene to help try and control the fire and provide support for any victims on the ground.
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The FAA said both the agency and the National Transportation Safety Board will investigate.
The Louisville Muhammad Ali International Airport remains closed while crews continue firefighting and investigation efforts.
Louisville is home to UPS's largest package handling facility. Around 300 flights a day leave from the hub.